Railroad Injury and Aplastic Anemia

Aplastic anemia is a blood disorder. It is caused by bone the marrow (springy tissue) stopping the production of new blood cells. These blood cells are needed to create red blood cells, which carry oxygen throughout the body, white blood cells that fight germs and platelets that help stop bleeding.

Chemotherapy and radiation treatments can also trigger aplastic aneurism through damaging stem cells within the bone marrow. If not treated, severe aplastic anemia can lead to death. Bone marrow transplant can help in younger people or in cases where medicine isn't working.

Benzene

The Department of Health and Human Services states that exposure to benzene used in rubber manufacturing and as a solvent for paints, inks, and other water-soluble substances, can damage the stem cells that make blood in your bone marrow. This could lead to aplastic anemia. It could also cause other blood cancers like myelodysplasia and leukemia. It can also affect the fertility of women, leading to irregular menstrual cycles as well as decreased fertility. In some cases exposure to benzene could cause cancer of the uterus as well as other reproductive organs.

Benzene is a non-polar, aromatic hydrocarbon. It is a known cancer-causing chemical, and the International Agency for Research on Cancer classifies it as a Group 1 Carcinogen. It is a well-known contaminant in the environment. It is found in petroleum products, gasoline as well as in plastics and dyes. Benzene can be absorbed through the skin's surface or inhaled. It is a solvent that has the ability to displace other chemicals. It can also interact with other chemicals, creating toxic metabolites that can disrupt the cell signaling pathways, and even hinder the growth of new blood cells.

The effects of benzene vary on the amount (dose) of chemical that you are exposed to, how it is absorbed into the skin or absorbed and the time of exposure. The xenobiotic metabolic process of the human body converts potentially harmful chemicals into metabolites that have fewer harmful impacts. However the synthesis of these metabolites can occur at locations that could result in negative effects on the human body, such as the inhibition of topoisomerase II, or covalent binding to proteins.

Organic Solvents

Aplastic anemia happens when stem cells in the bone marrow (the sponge-like tissue that makes blood cells) are damaged. Stem cells produce white blood cells, and platelets. Treatments for chemotherapy or radiation to treat other diseases can harm stem cells. Infections like hepatitis B or C, Epstein-Barr virus, parvovirus B19, Aplastic anemia railroad Injuries and HIV could play a part in anemia that is aplastic.

Exposure to benzene, which is a component of diesel fuel, increases the chance of developing aplastic anemia. People who work in the railroad yard or around engines of locomotives are at a high risk of exposure to benzene. This is especially true when exposure occurs over a long time. Other sources of benzene exposure include dry cleaners, metal degreasers and paint thinners and removers. These products contain chemicals like chloroform, trichloroethylene, vinyl chloride and methylbenzene.

Other risk factors for Aplastic anemia injuries anemia are exposure to toxins, use of certain drugs, and genetic diseases like Fanconi's anemia. Autoimmune diseases where the immune system attacks healthy tissues may be a contributing factor. Aplastic anemia railroad Injuries anemia usually occurs in those younger than 60. It also affects women more frequently than men. The majority of cases are idiopathic meaning that doctors don't know what causes these cases. The diagnosis is based on an extensive medical history, physical exam and blood tests like PNH Clones and bone marrow aspiration/biopsy.

Other Chemicals Toxic

Benzene isn't the only chemical that could cause aplastic anemia. Other toxic chemicals, such as herbicides and insecticides as well as organic solvents such as paint thinners, may increase the chance of developing aplastic ahememia. These chemicals can be inhaled or ingested, or absorbed by the skin. Exposure to these chemicals may cause many symptoms, including anemia fatigue, persistent or unprovoked blood or infection, bruising, Aplastic Anemia railroad injuries and skin rashes.

myeloma aplastic anemia anemia is a very serious blood disease, but it is hard to identify. Aplastic anemia's symptoms are similar to other illnesses and conditions. To make a diagnosis doctors must analyze your child's medical history and symptoms. They can conduct a variety of tests to determine the severity of aplastic ahememia, its cause, and whether it exists.

There are two kinds: acquired myeloma aplastic anemia as well as hereditary anemia. Hereditary anemia is transmitted through genes and is recognized in childhood. Aplastic anemia acquired can happen due to a variety of causes including chemotherapy and radiation from other treatments, infections and health conditions such as leukemia or hepatitis B or C. Some cases of aplastic anemia are idiopathic, meaning that they do not have a known cause. In the case of severe cases, doctors can perform a bone marrow transplant (BMT) that replaces damaged marrow with healthy blood-forming cells derived from donors.